On demand: from 8:00 AM at the airport or your accommodation in Iquitos.
On demand: from 9:00 AM to 7:00 PM at the airport or your accommodation in Iquitos. (suitable for flights leaving from 10:30 AM)
The most comfortable and safe way to reach Iquitos is by plane, since it is not connected to the road-network of the rest of the country. The majority of travelers arrives from Lima, where several airlines operate. Latam airline, however, is the only one that offers direct flights between Cusco and Iquitos.